Xovoltib 20mg (Afatinib Dimaleate)

Xovoltib 20mg (Afatinib Dimaleate) Tablets

Xovoltib 20mg contains afatinib dimaleate, a prescription kinase inhibitor used in the treatment of certain types of non-small cell lung cancer (NSCLC). Afatinib works by blocking specific signaling pathways that can help certain cancer cells grow and multiply.

Importantly, treatment with afatinib depends on the cancer type and molecular characteristics of the tumor. Therefore, a qualified healthcare professional should determine whether afatinib is appropriate for an individual patient.

What is Xovoltib 20mg?

Xovoltib 20mg is a tablet containing afatinib dimaleate. Afatinib belongs to a class of medicines known as kinase inhibitors. It interferes with signaling from the epidermal growth factor receptor (EGFR) and related pathways that can contribute to cancer-cell growth.

In the United States, afatinib tablets are approved for specific indications involving metastatic non-small cell lung cancer. The appropriate treatment depends on factors such as tumor type, EGFR mutation status, previous treatment, and overall clinical condition.

Xovoltib 20mg Uses

Xovoltib contains afatinib, which may be prescribed as part of treatment for certain forms of non-small cell lung cancer.

• Metastatic NSCLC with certain non-resistant EGFR mutations identified using an FDA-approved test.
• Metastatic squamous NSCLC that has progressed after platinum-based chemotherapy.

However, afatinib is not appropriate for every type of lung cancer. Your oncology team should confirm the diagnosis and relevant tumor biomarkers before treatment.

Afatinib for Lung Cancer

Afatinib is a targeted cancer treatment rather than a conventional cytotoxic chemotherapy drug. It blocks kinase signaling associated with the EGFR family, which can reduce signaling that promotes the growth and survival of certain cancer cells.

For EGFR mutation-positive metastatic NSCLC, tumor testing plays an important role in treatment selection. As a result, patients should discuss molecular testing and treatment options with their oncologist before starting afatinib.

Xovoltib 20mg Composition

The active pharmaceutical ingredient in Xovoltib 20mg is afatinib dimaleate, providing afatinib as the active moiety.

The exact inactive ingredients can vary by manufacturer and product. Always check the package insert or product labeling for the complete ingredient list, particularly if you have known allergies or intolerances.

How Does Afatinib Work?

Afatinib is a kinase inhibitor. It binds to and blocks signaling through members of the ErbB receptor family, including EGFR. These signaling pathways can contribute to the growth and spread of certain cancer cells.

Consequently, blocking these signals can slow the growth of tumors that depend on these pathways. The clinical benefit, however, depends on the patient’s specific cancer biology and treatment history.

How to Take Xovoltib 20mg

Take Xovoltib exactly as prescribed by your oncologist. Do not change the dose, frequency, or duration of treatment without medical advice.

U.S. prescribing information recommends taking afatinib on an empty stomach at least 1 hour before or 2 hours after eating. Take the tablet with water and follow the instructions provided with your prescription.

If you miss a dose and your next scheduled dose is within 12 hours, follow the prescribing information and skip the missed dose rather than taking a double dose.

Do not stop afatinib on your own. Your healthcare professional may adjust or temporarily interrupt treatment if significant adverse reactions occur.

Xovoltib 20mg Price

The price of Xovoltib 20mg can vary depending on the country, supplier, package size, prescription requirements, shipping arrangements, and availability.

For current product availability and pricing, visit our online medicine shop or browse the medicine categories.

For patients in the United States, prescription-drug availability and dispensing must comply with applicable federal and state requirements.

Xovoltib 20mg Side Effects

Afatinib can cause side effects. Some reactions are common and manageable, while others may require urgent medical attention.

Common Afatinib Side Effects

• Diarrhea
• Rash or acneiform dermatitis
• Dry skin
• Mouth sores or stomatitis
• Nail inflammation or paronychia
• Decreased appetite
• Nausea
• Vomiting
• Itching

Because diarrhea can become severe and lead to dehydration, contact your healthcare professional promptly if it is persistent, severe, or accompanied by weakness or reduced urination.

Serious Afatinib Side Effects

Some adverse reactions require immediate medical evaluation. Seek medical attention for symptoms such as severe or persistent diarrhea, significant skin reactions, breathing difficulties, eye pain or vision changes, severe abdominal pain, jaundice, or other unusual symptoms.

U.S. labeling includes important warnings concerning diarrhea, severe skin reactions, interstitial lung disease, liver toxicity, gastrointestinal perforation, keratitis, and embryo-fetal toxicity.

Xovoltib 20mg Precautions

Before taking afatinib, tell your healthcare professional about all medical conditions and medicines you use.

• Tell your doctor if you have liver or kidney problems.
• Report previous lung or breathing problems.
• Tell your doctor about heart conditions or eye problems.
• Report any severe or persistent diarrhea.
• Tell your healthcare professional about all prescription medicines, supplements, and herbal products.
• Avoid unnecessary or prolonged sun exposure because afatinib can increase skin sensitivity.

Furthermore, afatinib can cause fetal harm. People who are pregnant or may become pregnant should discuss contraception and pregnancy-related precautions with their healthcare professional.

Afatinib Drug Interactions

Afatinib can interact with other medicines. In particular, medicines that affect P-glycoprotein (P-gp) can change afatinib exposure.

Tell your doctor and pharmacist about every prescription medicine, over-the-counter product, vitamin, supplement, and herbal product you use. This information helps your healthcare team evaluate possible interactions and determine whether monitoring or dose adjustment is necessary.

Xovoltib 20mg Warnings

Xovoltib should be used only under appropriate medical supervision. Afatinib treatment requires monitoring for adverse reactions and may require dose modification or treatment interruption.

Contact your healthcare professional immediately if you develop severe diarrhea, serious skin reactions, breathing problems, eye symptoms, severe abdominal pain, unusual bleeding, yellowing of the skin or eyes, or other serious symptoms.

Xovoltib 20mg and Gilotrif

Gilotrif is the U.S. brand name for afatinib. Xovoltib is a separate branded product containing afatinib dimaleate. Therefore, patients should not assume that different brands have identical regulatory status, packaging, availability, or approval in every country.

The FDA approved the first generic versions of Gilotrif (afatinib tablets) on July 14, 2026. The approved U.S. generic indications include specific EGFR mutation-positive metastatic NSCLC and metastatic squamous NSCLC progressing after platinum-based chemotherapy.

FDA Information About Afatinib

Afatinib received its initial U.S. approval in 2013. Current U.S. labeling identifies afatinib as a kinase inhibitor for specific metastatic NSCLC indications. The current U.S. label also includes 20mg, 30mg, and 40mg tablet strengths.

Importantly, FDA approval of afatinib does not automatically mean that every international brand or specific package is FDA-approved. Patients should verify the exact product and manufacturer when purchasing prescription medicines for use in the United States.

MedlinePlus: Afatinib Drug Information

FDA: First Generic Afatinib Approvals

DailyMed: Afatinib Tablets Prescribing Information

Xovoltib 20mg Substitutes

Possible alternatives to afatinib depend on the cancer type, biomarker results, previous treatment, overall health, and treatment goals.

Other targeted medicines may be considered by an oncologist when clinically appropriate. However, medicines such as osimertinib or erlotinib are not automatically interchangeable with afatinib. Your doctor should select an alternative based on your specific diagnosis and tumor characteristics.

Frequently Asked Questions About Xovoltib 20mg

What is Xovoltib 20mg used for?

Xovoltib 20mg contains afatinib and may be prescribed for certain types of metastatic non-small cell lung cancer. Treatment selection depends on tumor type and molecular characteristics.

Is Xovoltib 20mg a chemotherapy medicine?

Afatinib is a targeted kinase inhibitor rather than a traditional cytotoxic chemotherapy drug. It targets signaling pathways involved in certain cancer cells.

What is the active ingredient in Xovoltib 20mg?

The active ingredient is afatinib, supplied as afatinib dimaleate.

Can I take Xovoltib 20mg without a prescription?

No. Afatinib is a prescription cancer medicine and should be used only under the supervision of a qualified healthcare professional.

When should Xovoltib be taken?

U.S. prescribing information recommends taking afatinib on an empty stomach at least 1 hour before or 2 hours after food. Follow the exact instructions provided by your prescriber.

Can Xovoltib cause diarrhea?

Yes. Diarrhea is one of the most common adverse reactions associated with afatinib. Severe or persistent diarrhea should be reported to a healthcare professional promptly.

Is Xovoltib 20mg FDA approved?

The FDA has approved afatinib products in the United States, including generic afatinib tablets. However, FDA approval of the active medicine does not establish that the specific Xovoltib brand shown on this page is FDA-approved for U.S. marketing.

Buy Xovoltib 20mg Online

If you are looking for Xovoltib 20mg, review the product information, strength, packaging, availability, and prescription requirements carefully before ordering.

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U.S. Regulatory Notice: Xovoltib is an internationally branded prescription medicine. Availability, dispensing, importation, and use of prescription medicines in the United States are subject to applicable federal and state laws. Do not assume that an international brand is FDA-approved simply because its active ingredient has an FDA-approved product. Verify the exact product and regulatory status with a licensed healthcare professional and the appropriate U.S. regulatory resources.

Medical Disclaimer

This product information is provided for educational purposes only and does not replace professional medical advice, diagnosis, or treatment. Xovoltib 20mg (afatinib dimaleate) should be used only according to a qualified healthcare professional’s prescription and instructions.

Do not start, stop, or change cancer treatment based solely on information on this website. Always discuss potential benefits, risks, drug interactions, pregnancy considerations, and monitoring requirements with your oncologist or pharmacist.